A natural product is described as a compound or substance produced by a living organism found in nature. For thousands of years, many cultures around the world have depended on traditional medicines found in nature. Over the last hundred years, many new FDA approved drugs have their origins in natural products and many of these are also used in commercial products including cosmetic and beauty products and dietary supplements.
Natural products can be both chemically synthesized or isolated from natural sources such as plant and tissue extracts, fermentation broths, etc. Active agents from natural sources are typically found in very low levels and must be extracted and purified to higher concentrations to demonstrate their specific activity. Gilson has a range of extraction and purification products to benefit your natural products workflows and more information can be found in our natural product-focused application notes.
Preparative high performance liquid chromatography (HPLC) is a well-established method for purifying target compounds. Method development is usually done at a smaller scale to define sufficient resolution between the peaks without wasting large amounts of sample. It is common to scale-up the purification from a smaller column to a larger preparative one - learn more in this technical note.
Vanillin is the major component of natural vanilla, which is one of the most widely used flavoring materials worldwide. In this app note, an ethanolic crude extract of vanilla is used to show the capacity of the PLC 2050 system to work with different types of chromatographic columns.
The VERITY® CPC Lab MS System allows you to perform mass-directed purification of target compounds by centrifugal partition chromatography (CPC). This automated, cost-effective, liquid-liquid purification technique utilizes reusable, silica-free chromatographic columns and the VERITY® 1920 Mass Spectrometer to streamline your workflow and allow you to quickly isolate added value molecules with high yields and purity.
This ASPEC® system for positive pressure solid phase extraction (SPE) maximizes throughput by processing up to four samples in parallel. With its small footprint and multiple probes, it is the ideal choice for high-throughput SPE automation on 1, 3, or 6 mL cartridges. Combined with ASPEC SPE Cartridges, it generates reproducible and efficient sample cleanup for clinical, forensic, doping, food, and environmental testing labs.
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